Volumetric correlates of cognitive functioning in nondemented patients with Parkinson's disease.
Identifieur interne : 000362 ( Main/Exploration ); précédent : 000361; suivant : 000363Volumetric correlates of cognitive functioning in nondemented patients with Parkinson's disease.
Auteurs : J Vincent Filoteo [États-Unis] ; Jason D. Reed ; Irene Litvan ; Deborah L. HarringtonSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Cognition (physiology), Cognition Disorders (complications), Cognition Disorders (diagnosis), Cognition Disorders (pathology), Dementia (complications), Dementia (diagnosis), Dementia (pathology), Executive Function (physiology), Female, Humans, Magnetic Resonance Imaging (methods), Male, Memory (physiology), Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (pathology).
- MESH :
- complications : Cognition Disorders, Dementia, Parkinson Disease.
- diagnosis : Cognition Disorders, Dementia, Parkinson Disease.
- methods : Magnetic Resonance Imaging.
- pathology : Cognition Disorders, Dementia, Parkinson Disease.
- physiology : Cognition, Executive Function, Memory.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neuropsychological Tests.
Abstract
A challenge in Parkinson's disease (PD) is to identify biomarkers of early cognitive change because functioning in some domains may be more prognostic of dementia. Few studies have investigated whether structural magnetic resonance imaging (MRI) correlates in a regionally specific manner with functioning in different cognitive domains. The aim of this study was to identify neuroanatomical correlates of executive functioning, memory, and visual cognition in PD without dementia. 3T MRI was conducted in 51 PD patients and 39 control participants. Brain volumes were measured in structures comprising the frontostriatal cognitive-control system, the medial temporal memory system, the ventral object-based system, and the dorsal spatial-based system. Measures of executive functioning (Stroop Test; Letter Fluency), memory (California Verbal Learning Test), visuospatial cognition (Judgment of Line Orientation), and visuoconstruction (Pentagon Copy) were correlated with volumes comprising each system. Poorer executive functioning largely correlated with decreased frontostriatal volumes. Poorer memory correlated with decreased volumes in all medial temporal regions, but also with frontostriatal volumes. Poorer visuospatial cognition correlated with decreased volumes in the object-based system, whereas poorer visuoconstruction correlated with decreased frontal and object-based system volumes. These relationships were nonsignificant in the control group. This is the first study to demonstrate that subtle changes in multiple cognitive domains in PD without dementia correlate with regional volumes in specific systems implicated in the development of cognitive impairment. The findings suggest that structural MRI holds promise as a marker of early changes in different brain systems, some of which may predict future cognitive deterioration.
DOI: 10.1002/mds.25633
PubMed: 24038502
Affiliations:
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Le document en format XML
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Reed</name></author><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name></author><author><name sortKey="Harrington, Deborah L" sort="Harrington, Deborah L" uniqKey="Harrington D" first="Deborah L" last="Harrington">Deborah L. Harrington</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24038502</idno><idno type="pmid">24038502</idno><idno type="doi">10.1002/mds.25633</idno><idno type="wicri:Area/PubMed/Corpus">000772</idno><idno type="wicri:Area/PubMed/Curation">000772</idno><idno type="wicri:Area/PubMed/Checkpoint">000363</idno><idno type="wicri:Area/Ncbi/Merge">003D24</idno><idno type="wicri:Area/Ncbi/Curation">003D24</idno><idno type="wicri:Area/Ncbi/Checkpoint">003D24</idno><idno type="wicri:Area/Main/Merge">000362</idno><idno type="wicri:Area/Main/Curation">000362</idno><idno type="wicri:Area/Main/Exploration">000362</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Volumetric correlates of cognitive functioning in nondemented patients with Parkinson's disease.</title><author><name sortKey="Filoteo, J Vincent" sort="Filoteo, J Vincent" uniqKey="Filoteo J" first="J Vincent" last="Filoteo">J Vincent Filoteo</name><affiliation wicri:level="2"><nlm:affiliation>Psychology Service, VA San Diego Healthcare System, San Diego, California, USA; Research Service, VA San Diego Healthcare System, San Diego, California, USA; Department of Psychiatry, University of California, San Diego, San Diego, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Psychology Service, VA San Diego Healthcare System, San Diego, California, USA; Research Service, VA San Diego Healthcare System, San Diego, California, USA; Department of Psychiatry, University of California, San Diego, San Diego, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Reed, Jason D" sort="Reed, Jason D" uniqKey="Reed J" first="Jason D" last="Reed">Jason D. Reed</name></author><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name></author><author><name sortKey="Harrington, Deborah L" sort="Harrington, Deborah L" uniqKey="Harrington D" first="Deborah L" last="Harrington">Deborah L. Harrington</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cognition (physiology)</term><term>Cognition Disorders (complications)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (pathology)</term><term>Dementia (complications)</term><term>Dementia (diagnosis)</term><term>Dementia (pathology)</term><term>Executive Function (physiology)</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Memory (physiology)</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (pathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cognition Disorders</term><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cognition Disorders</term><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term><term>Executive Function</term><term>Memory</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A challenge in Parkinson's disease (PD) is to identify biomarkers of early cognitive change because functioning in some domains may be more prognostic of dementia. Few studies have investigated whether structural magnetic resonance imaging (MRI) correlates in a regionally specific manner with functioning in different cognitive domains. The aim of this study was to identify neuroanatomical correlates of executive functioning, memory, and visual cognition in PD without dementia. 3T MRI was conducted in 51 PD patients and 39 control participants. Brain volumes were measured in structures comprising the frontostriatal cognitive-control system, the medial temporal memory system, the ventral object-based system, and the dorsal spatial-based system. Measures of executive functioning (Stroop Test; Letter Fluency), memory (California Verbal Learning Test), visuospatial cognition (Judgment of Line Orientation), and visuoconstruction (Pentagon Copy) were correlated with volumes comprising each system. Poorer executive functioning largely correlated with decreased frontostriatal volumes. Poorer memory correlated with decreased volumes in all medial temporal regions, but also with frontostriatal volumes. Poorer visuospatial cognition correlated with decreased volumes in the object-based system, whereas poorer visuoconstruction correlated with decreased frontal and object-based system volumes. These relationships were nonsignificant in the control group. This is the first study to demonstrate that subtle changes in multiple cognitive domains in PD without dementia correlate with regional volumes in specific systems implicated in the development of cognitive impairment. The findings suggest that structural MRI holds promise as a marker of early changes in different brain systems, some of which may predict future cognitive deterioration.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><noCountry><name sortKey="Harrington, Deborah L" sort="Harrington, Deborah L" uniqKey="Harrington D" first="Deborah L" last="Harrington">Deborah L. Harrington</name><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><name sortKey="Reed, Jason D" sort="Reed, Jason D" uniqKey="Reed J" first="Jason D" last="Reed">Jason D. Reed</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Filoteo, J Vincent" sort="Filoteo, J Vincent" uniqKey="Filoteo J" first="J Vincent" last="Filoteo">J Vincent Filoteo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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